Geoff Zanelli

The doctors of Grey Sloan Memorial Hospital deal with life-or-death consequences on a daily basis -- it's in one another that they find comfort, friendship and, at times, more than friendship. Together they're discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.

The Simpsons is the longest running scripted show in US television history. It captures the adventures of Homer, Marge, Maggie, Bart and Lisa who are living in a fictional town called Springfield.

Futurama follows pizza guy Philip J. Fry, who reawakens in 31st century New New York after a cryonics lab accident. Now part of the Planet Express delivery crew, Fry travels to the farthest reaches of the universe with his robot buddy Bender and cyclopsian love interest Leela, discovering freaky mutants, intergalactic conspiracies and other strange stuff.

Family Guy follows Peter Griffin the endearingly ignorant dad, and his hilariously offbeat family of middle-class New Englanders in Quahog, RI. Lois is Peter's wife, a stay-at-home mom with no patience for her family's antics. Then there are their kids: 18-year-old Meg is an outcast at school and the Griffin family punching bag; 13-year-old Chris is a socially awkward teen who doesn't have a clue about the opposite sex; and one-year-old Stewie is a diabolically clever baby whose burgeoning sexuality is very much a work in progress. Rounding out the Griffin household is Brian the family dog and a ladies' man who is one step away from AA.

Across continents and decades, five brilliant friends make earth-shattering discoveries as the laws of science unravel and an existential threat emerges.